# ========================
# OS
# ========================
.DS_Store
.AppleDouble
.LSOverride
Thumbs.db
ehthumbs.db
Desktop.ini
$RECYCLE.BIN/

# ========================
# Editors & IDEs
# ========================
.vscode/
.idea/
.cursor/
*.swp
*.swo
*~

# ========================
# Python
# ========================
__pycache__/
*.py[cod]
*$py.class
*.so
*.egg
*.egg-info/
.eggs/
MANIFEST
.Python
.python-version
.installed.cfg
pip-log.txt
pip-delete-this-directory.txt

# Distribution / packaging
build/
dist/
develop-eggs/
downloads/
eggs/
lib/
lib64/
parts/
sdist/
var/
wheels/
share/python-wheels/
pip-wheel-metadata/

# PyInstaller
*.manifest
*.spec

# ========================
# Virtual Environments
# ========================
.venv
venv/
env/
ENV/
venv.bak/
env.bak/
__pypackages__/

# ========================
# Environment & Secrets
# ========================
.env
.env.alphavx
.env.local
.env.prod
.env.dev
.env.*.local
*.pem
*.key

# ========================
# Testing & Coverage
# ========================
.tox/
.nox/
.coverage
.coverage.*
.cache/
.hypothesis/
.pytest_cache/
htmlcov/
nosetests.xml
coverage.xml
*.cover
*.py,cover

# ========================
# Type Checkers & Linters
# ========================
.mypy_cache/
.dmypy.json
dmypy.json
.pyre/

# ========================
# Frameworks
# ========================

# Django
local_settings.py
db.sqlite3
db.sqlite3-journal

# Flask
instance/
.webassets-cache
flask_session/

# Scrapy
.scrapy

# Celery
celerybeat-schedule
celerybeat.pid

# ========================
# Docs & Notebooks
# ========================
docs/_build/
.ipynb_checkpoints
profile_default/
ipython_config.py
/site

# ========================
# Databases
# ========================
*.db
*.sqlite

# ========================
# Logs & Temp
# ========================
*.log
*.tmp
*.temp

# ========================
# Node (occasional use)
# ========================
node_modules/

# ========================
# Misc
# ========================
target/
.ropeproject
.spyderproject
.spyproject
Trash/

# ========================
# AlphaVX specific
# ========================
results/
cache/
*.db
alphavx_cache.db
*.vcf.gz
clinvar*.vcf*