Architecture Reference — Diagram 02

Design Iteration Loop

AGENTIC DRUG DISCOVERY PLATFORM
ONE ACTIVE-LEARNING ROUND · BLOCKS A–E
Target Agent dossier from literature Design Agent N candidates · tournament Evaluation Harness benchmarks · Elo rank In-silico Assays docking · MD · ADMET Human Gate sandbox paused dossier candidates top-K survivors Assay Planning abstract protocol Lab Execution safety · IAL · instruments Analysis Agent findings · proposals Provenance Store every hop recorded approved AssayResult next_round_proposals — active learning loop SANDBOX SUBSTRATE (AGENTENV · L3) fork per experiment branch snapshot at the human gate replay for audits SOLID = DATA/CONTROL FLOW · GREEN = ITERATION FEEDBACK · VIOLET = PROVENANCE WRITES (EVERY HOP)
Orchestration / agents Agent workforce Human gate Infrastructure / provenance

One round of the active-learning loop. Everything flows through the orchestration spine as StageTasks (agents) and ToolInvocations (services); the human gate pauses the sandbox branch so full agent context survives review latency. Confirmed results return as next_round_proposals and also feed Block C's fine-tuning flywheel.